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Gene therapy is a method for treating inherited diseases by delivering corrective versions of genes to patients. Dr. Jean Bennett and Dr. Albert Maguire focused their careers on developing a successful gene therapy for an inherited form of childhood blindness called Leber congenital amaurosis (LCA). This documentary tells the story of how the LCA gene therapy was developed. Students will learn how autosomal recessive conditions are inherited, how scientists can use modified viruses to deliver human genes to cells, what makes the eye an ideal tissue for gene therapy, and how model organisms are used to test treatments before they are tested in patients.
(Source: DCMP)
Genes, those traits passed down to us by our parents, are the things that make each of us different from the others. This question-answer format covers basic information about genes, chromosomes, cell division, dominant and recessive genes, and fertilization. Illustrates Mendel's rules of heredity. Covers advances in the fields of DNA, genetic engineering, and gene therapy. Reviews major points.
Watch the story of how gene therapy restored the sight of a nearly-blind young patient. Told from the perspective of two researchers who spent over 25 years working to develop this breakthrough technology, this short film chronicles their successes and challenges, and illustrates how the method works to treat inherited conditions.
To what degree are we genetically programmed with certain traits and abilities? Looks at recent technologies and scientific discoveries and considers the classic "nature versus nurture" discussion. Segments cover identical twins, the science of biotechnology, and the genetic inheritance of working dogs. Investigates the similarities in personality shared by identical twins. Explains how recent breakthroughs in genetics research and DNA have created new ways to solve crimes, breed (clone) animals, and extend human life. Discusses cross-species cloning, human cloning, and gene therapy. Shows how assistance and search-and-rescue dogs can be taught to overcome their inborn instincts and fear.
Researchers see promise in using an off-the-shelf fabric in athletic coaching and physical therapy, and another group of scientists are studying how pyroclastic flows defy friction. Other segments include new techniques to test for viral infections and the design of a new robot. Part of the "4 Awesome Discoveries You Probably Didn't Hear About This Week" series.
Every year, a million babies are born worldwide with hereditary diseases. Physicians once had little to offer. Now a new breed of gene doctors is on the case. They are devising treatments that target the root causes of these diseases. Please note this title contains potentially offensive language.
No organism lives forever. The length of time animals and humans live is influenced by their genes. Scientists have made astonishing discoveries concerning the role of genetics in determining life span, and this holds promise of extending the lives of animals and humans. Explains genetics, DNA, and genetic theories of aging. Illustrates the genetic processes behind cellular aging, and shows how genes affect life span. Discover the reasons why cells age and why a certain enzyme can effectively turn back the hands of our "biological clock."
Genetic modification of organisms and cloning is controversial. Looks at the way humanity has modified genomes of plants and animals used for food since the dawn of agriculture. As knowledge of cells and genetics has increased, so has humanity's ability to alter genomes. Shows animations of how genetic engineers are now able to construct and insert genes for desirable characteristics into plants and how technology is used to increase numbers of animals with desirable traits and screen out those with disease or lower food yields.
Part of the "A 3-D Demonstration" series. Looks at physics principles behind AC and DC generators. Examines the relationship between a changing magnetic field and the induction of electric current. A hand rule is introduced to predict the generator effect in a linear length of conductor exposed to a changing magnetic field. The behavior of a rotating coil in a magnetic field leads to the practical construction of an AC motor. Introduces split-ring commutator generators, as well as the more common alternator as a means of generating DC electricity. Specific modules include Generating Electricity, Inductors, Generator Left-Hand Rule, Generator Electromotive Rule, AC Generators, and DC Generators. Correlates to all National CTE Organizational Standards (including the provisions of the Perkins Act).
Nature vs. Nurture is a long-running debate in the social sciences. While human genetics is an important part of the story, recent scientific developments suggest that the way genes actually work can be critically shaped by the environment in which one lives. Dr. Nessa Carey and Dr. Guy Sutton explore the ways epigenetics gives a new and exciting dimension to the debate.
Explore the natural gene bank of the domestic apple located in Central Asia. Viewers learn about efforts to preserve the genetic diversity of apples. Scientists are using conservation and genetic engineering to aid the process. Part of "The Botany of Desire" series.
Part of the "Visualizing Cell Processes" series. Includes the following modules: "The Protein Nature of Life," "Protein Structure," "Transcription," "Translation and Protein Synthesis," "Gene Regulation in Prokaryotes," "Classes of Eukaryote DNA," "Exons and Introns," "Mutations," and "Renegade DNA: The Viruses."
Butterfly metamorphosis is still a bit of a mystery. What happens inside a chrysalis to turn a caterpillar into a beautifully painted butterfly? In this episode, host Joe Hanson interviews Dr. Arnaud Martin, who uses the CRISPR genetic modification technology to learn about how genes build butterfly wings. Part of the "It's Okay to Be Smart" series.
Identifying the key molecular players in planarian regeneration may offer clues into how the process may work in other species, including humans. HHMI investigator Alejandro Sánchez Alvarado and postdoctoral fellow Alice Accorsi use RNA-mediated genetic interference (RNAi) to silence different genes in planaria and determine how they affect regeneration.
For life to survive, it must adapt and readapt to an ever-changing Earth. The discovery of the Antarctic icefish has provided an example of adaptation in an environment both hostile and abundant, where the birth of new genes and the death of old ones have played crucial roles. Researchers Bill Detrich, Christina Cheng, and Art DeVries have pinpointed the genetic changes that enable icefish to thrive without hemoglobin and red blood cells and to avoid freezing in the icy ocean.
Mosquitoes spread several viruses, including Dengue, Chikungunya, Yellow Fever, and Zika. Health officials are developing various methods to help reduce the spread of infections. One of those methods is to produce genetically modified mosquitoes that, when released into the wild, reproduce with wild mosquitoes and cause their offspring to die.
Human babies drink milk; it's the food especially provided for them by their mothers. Various cultures have also added the milk of other mammals to their diet, and adults think nothing of downing a glass of cows' milk. But worldwide, only a third of adults can actually digest lactose, the sugar in milk. Human geneticist Spencer Wells tracks down the genetic changes associated with the ability to digest lactose as adults. Combining genetics, chemistry, and anthropology, this story provides a compelling example of the co-evolution of human genes and human culture.
Investigates the reasons why cattle and humans have been linked together for over 30,000 years. Analyzes the anatomy of the cow's stomach, detailing the purpose of each chamber. Visit the Masai with their cattle herds and the sacred cows of India. Introduces the main cattle breed of the 800 breeds developed in England, explaining how artificial selection is used to produce desirable characteristics. Also introduces British dairy cow detailing the working of the udder and teats and the use of genetic engineering to increase milk production. Interviews Eric Schlosser, an author about the development of slaughterhouse methods in America. Also visits a family ranch where cattle are being raised in natural conditions under a grass management system.
This video introduces science lab safety guidelines. Some topics covered include discussions on proper lab attire, importance of proper disposal of materials, and precautions when heating substances. Part of "The Amoeba Sisters" series.
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Biology related concepts
A collection containing 59 resources, curated by Benetech
Resources to teach younger students about animals
A collection containing 58 resources, curated by DIAGRAM Center
